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Many major historical figures in philosophy have provided an answer to the question of what, if anything, makes life meaningful, although they typically have not put it in these terms. Consider, for instance, Aristotle on the human function, Aquinas on the beatific vision, and Kant on the highest good.



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Peptides can be modified at the N terminus, in the middle, or at the C terminus. In general, some standard peptide moieties must be accessible in order to be modified:



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The purified PAL catalytic core PALcc contains molar equivalents of calcium and zinc along with substoichiometric amounts of iron and functions as a ureidoglycolate lyase. Limiting iron availability in the cells synthesizing PALcc reduces the specific activity of the enzyme produced.

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This approach significantly reduced the number of spectra requiring interpretation, decreasing the computing time required for database searching and enabling manual interpretation of unidentified spectra. Amidation at the C-terminus is an important post-translational modification common to many neuropeptides Figure 1A.



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We report a case study of an IgG1 with a unique basic charge variant profile caused by C-terminal proline amidation on either one or two heavy chains. The proline amidation was sensitive to copper ion concentration in the production media during cell culture:

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In this chapter, it is argued that meaning in life is an important variable for human well-being.

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